JINTERNMED: How is the risk of thromboembolic in patients with huge cytometry and / or rheumatic polymyaline?

JINTERNMED: How is the risk of thromboembolic in patients with huge cytometry and / or rheumatic polymyaline?

Great cytometry (GCA) and rheumatoid polymyalia (PMR) are systematic inflammatory diseases that affect elderly women.

Recently, a research article published in Journal of Internal Medicine, which is aimed at comparing the risk of thromboembolic incident and retinal angiogenesis in patients with GCA and / or PMR.

In this retrospective study, a total of 1535 GCA patients, 10,265 PMR patients and 1203 patients with mergers of two diseases, and 39009 ages and gender matched OA patients. Over time, researchers calculate and assess pulmonary embolism (PE), deep vein thrombus formation (DVT), arterial thromboese (ATE), retinal central artery blocking (CRAO) and retinal central vein blocking (CRVO) Rate ratio (IRR). The researchers plot the accumulation rate and calculate the risk ratio of thromboembolic incidents, and adjusted the independent risk factors of thromboembolism.

All thromboembolic incidents have higher IRR in patients with GCA and two diseases compared to OA patients. Patients with two diseases combined with two diseases (HRs were 2.01, 95% CI of 1.35-2.99, P <0.001; HR of 2.37, 95% CI is 1.23-4.53, P = 0.009) or patients alone (there is respectively HR was 1.89, 95% Ci is 1.50-2.41, P <0.001; HR is 4.68, 95% CI is from 3.10 to 7.07, P <0.001, each), and the risk of DVT and retinal angiogenesis occurred higher than patients with GCA. The risk of PE was higher than that of PMR patients (HR was 1.55, 95% CI) of PMR patient (HR was 1.55, and 0.01).

It can be seen that the risk of thromboembolic incident incident occurred in GCA, PMR, and two diseases. Researchers have found that the risk of thromboembolic incidents may be predicted according to the disease phenotype.

Original source:

Despina Michailidou, et al.Risk of venous and arterial thromboembolism in patients with giant cell arteritis and / or polymyalgia rheumatica: A Veterans Health Administration population-based study in the United States.Journal of Internal Medicine.2022.https: // onlinelibrary. Wiley.com/doi/10.1111/joim.13446

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